葉秀慧 教授

聯絡電話:02-2312-3456 轉 88284 or 66644




Hepatitis B virus in liver pathogenesis
Molecular virology of hepatitis B virus and coronaviruses
Sex hormone in liver biology and diseases


Ph. D., Department of Molecular Medicine, College of Medicine at National Taiwan University


1998-2001: Post Doc., NHRI & Hepatitis Research Center, National Taiwan University Hospital, Taiwan.
2001-2005: Assistant Investigator, Division of Molecular &Genome Medicine, National Health Research Institutes, Taiwan.
2005-2006: Assistant Professor, Department of Microbiology, National Taiwan University College of Medicine, Taiwan.
2006-2010: Associate Professor, Department of Microbiology, National Taiwan University College of Medicine, Taiwan.
2010-present: Professor, Department of Microbiology, National Taiwan University College of Medicine, Taiwan.

科技部傑出研究獎 (2014)
國科會傑出研究獎 (2010)



1. Carcinogenic mechanisms of HBV related HCC

(1) Sex hormones, including androgen or estrogen, and microRNAs in regulating the gender difference of HBV related HCC.

(2) Sex hormones in liver biology, including metabolism, angiogenesis, and protein degradation.

(3) The mechanisms for hepatic stem cells to liver cancers.

(4) Targeted cancer therapy of HCC.

2.  Basic virology research for the virus related infectious disease(s)

(1) Functional study for the phosphorylation of viral nucleocapsid proteins, including HBV and coronaviruses.

(2) Antiviral drug development.





Selected publications
1. +Chiu CM, +Yeh SH, Chen PJ, Kuo TJ, Chang CJ, Chen PJ, Yang WJ, Chen DS*. Hepatitis B virus X protein enhances androgen receptor-responsive gene expression depending on androgen level. Proc. Natl. Acad. Sci. USA. 104(8):2571-8, 2007. (+, equal contribution)
2. Liu WH, Yeh SH*, Lu CC, Yu SL, Chen HY, Lin CY, Chen DS, Chen PJ. MicroRNA-18a prevents estrogen receptor-alpha expression, promoting proliferation of hepatocellular carcinoma cells. Gastroenterology. 136:683-93, 2009.
3. +Yang WJ, +Chang CJ, Yeh SH*, Lin WH, Chen DS, Chen PJ. HBV X protein enhances the transcriptional activity of the androgen receptor through c-Src and glycogen synthase kinase- 3 beta kinase pathways. Hepatology. 49:1515-24, 2009.
4. Wu CH, Yeh SH*, Tsay YG, Shieh YH, Chen YS, Wang SH, Kao CL, Kuo TJ, Chen DS, Chen PJ. Glycogen synthase kinase-3 regulates the phosphorylation of Sars-coronavirus nucleocapsid protein and viral replication. J Biol Chem. 284:5229-5239, 2009.
5. Wang SH, Yeh SH*, Lin WH, Wang HY, Chen DS, Chen PJ. Identification of androgen response elements in the enhancer I of hepatitis B virus: a mechanism for gender disparity in chronic hepatitis B. Hepatology, 50:1392-1402, 2009.
6. +Tao Y, +Ruan J, +Yeh SH, +Lu X, +Wang Y, +Zhai W, +Cai J, Ling S, Gong Q, Chong Z, Qu Z, Li Q, Liu J, Yang J, Zheng C, Zeng C, Wang HY, Zhang J, Wang SH, Hao L, Dong L, Li W, Sun M, Zou W, Yu C, Li C, Liu G, Jiang L, Xu J, Huang H, Li C, Mi S, Zhang B, Chen B, Zhao W, Hu S, Zhuang SM, Shen Y, Shi S, Brown C, White KP, Chen DS, Chen PJ*, Wu CI*. Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data. Proc. Natl. Acad. Sci. USA. 108(29):12042-7, 2011. (+, equal contribution)
7. Wang EY, Yeh SH*, Tsai TF, Huang HP, Jeng YM, Lin WH, Chen WC, Yeh KH, Chen PJ, Chen DS*. Depletion of beta-catenin from mature hepatocytes of mice promotes expansion of hepatic progenitor cells and tumor development. Proc. Natl. Acad. Sci. USA. 108(45):18384-9, 2011.
8. Wang SH, Yeh SH*, Lin WH, Yeh KH, Yaun Q, Xia NS, Chen DS, Chen PJ. Estrogen receptor alpha represses hepatitis B virus transcription by squelching essential hepatocyte nuclear factor 4 alpha. Gastroenterology. 2012 Apr;142(4):989-998.e4.
9. Hsiao CC, Chang J, Wu JY, Liu WH, Han SY, Chen PJ, Yeh SH*. High resolution melting combines with real-time PCR for quantification and detection of drug-resistant hepatitis B virus mutants in a single PCR amplicon. Antivir Ther. 2012;17(2):291-303.
10. Chen PJ, Yeh SH*, Liu WH, Lin CC, Huang HC, Chen CL, Chen DS, Chen PJ. Androgen pathway stimulates microRNA-216a transcription to suppress the TSLC1 tumor suppressor gene in early hepatocarcinogenesis. Hepatology. 2012 Aug;56(2):632-43.
11. Lin WH, Yeh SH*, Yang WJ, Yeh KH, Fujiwara T, Nii A, Chang SS, Chen PJ. Telomerase-specific oncolytic adenoviral therapy for orthotopic hepatocellular carcinoma in HBx transgenic mice. Int J Cancer. 2013 Mar 15;132(6):1451-62.
12. Liu WH, Chen CH, Yeh KH, Li CL, Wu YJ, Chen DA, Chen PJ, Yeh SH*.  ADAR2-Mediated Editing of miR-214 and miR-122 Precursor and Antisense RNA Transcripts in Liver Cancers. PLoS One. 2013 Dec 27;8(12):e81922.
13. Wu CH, Chen PJ, Yeh SH*. Nucleocapsid phosphorylation and RNA helicase DDX1 recruitment enables coronavirus transition from discontinuous to continuous transcription. Cell Host Microbe. 2014 Oct 8;16(4):462-72.
14. Li CL, Yeh KH, Liu WH, Chen CL, Chen DS, Chen PJ, Yeh SH*. Elevated p53 promotes the processing of miR-18a to decrease estrogen receptor-α in female hepatocellular carcinoma. Int J Cancer. 2015 Feb 15;136(4):761-70.
15. Wang SH, Chen PJ, Yeh SH*. Gender Disparity in Chronic Hepatitis B: Mechanisms of Sex Hormones. J Gastroenterol Hepatol. 2015 Feb 24. [Epub ahead of print]


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