鄧述諄 Professor

聯絡電話:02-23123456 ext. 88294 (O), 88282 (L)




Chromosome Dynamics and Aging


PhD in Biochemistry, Rutgers University


Visiting Fellow in Molecular Biology, Princeton University




Research in our lab is centered around the molecular basis of genome dynamics and regulation in aging by systematically identifying both enzymatic and structural components involved in the chromosome dynamics, stress response and aging pathways, and characterizing how these proteins work. Genomic instability is the leading cause for disease and telomere maintenance is a required step for longevity. We take advantage of the genetically tractable model organism yeast Saccharomyces cerevisiae to approach these questions and use our findings in yeast to extend our studies in mammalian cells, since the fundamental mechanisms of these pathways are preserved from yeast to human. 






All medical treatments begin with basic research that reveals how biological systems function at every level, from molecules to cells to organisms. Our goal is to use the knowledge discovered from our basic research to ultimately mitigate illnesses or extend life. The Teng laboratory is always eager to hear from outstanding students and postdoctors who are ambitious, are dedicated, love science and are interested in doing research with us.





Selected Publications:

* Kao L, Wang YT, Chen YC, Tseng SF, Jhang JC, Chen YJ, Teng SC. Global analysis of Cdc14 dephosphorylation sites reveals essential regulatory role in mitosis and cytokinesis. (2014) Molecular & Cellular Proteomics, 13, 594-605.

* Shen ZJ, Hsu PH, Su YT, Yang CW, Kao L, Tseng SF, Tsai MD, Teng SC. PP2A and Aurora differentially modify Cdc13 to promote telomerase release from telomeres at G2/M phase. (2014) Nature Communications, 5:5312 doi: 10.1038/ncomms6312.

* Chang YL, Hsieh MH, Chang WW, Wang HY, Lin MC, Wang CP, Lou PJ, Teng SC. Instability of succinate dehydrogenase in SDHD polymorphism connects reactive oxygen species production to nuclear and mitochondrial genomic mutations in yeast. (2015) Antioxidants & Redox Signaling, 22, 587-602

* Hsieh MS, Tsai CH, Lin CC, Li TK, Hung TW, Chang LT, Hsin LW, Teng SC. Topoisomerase II inhibition suppresses the proliferation of telomerase-negative cancers. (2015) Cellular and Molecular Life Sciences, 72, 1825-1837

* Tsai CH, Chen YJ, Yu CJ, Tzeng SR, Wu IC, Kuo WH, Lin MC, Chan NL, Wu KJ, Teng SC. SMYD3-mediated H2A.Z.1 methylation promotes cell cycle and cancer proliferation. (2016) Cancer Research, 76, 6043-6053.

* Yang CW, Tseng SF, Yu CJ, Chung CY, Chang CY, Pobiega S, Teng SC. Telomere shortening triggers a feedback loop to enhance end protection. (2017) NAR, 45, 8314-8328.

* Chang YL, Tseng SF, Huang YC, Shen ZJ, Hsu PH, Hsieh MH, Yang CW, Tognetti S, Canal B, Subirana L, Wang CW, Chen HT, Lin CY, Posas F, Teng SC. Multiple pathways activate Cip1 to inhibit Cdk1-G1 cyclins upon stress. (2017) Nature Communications, DOI:s41467-017-00080-y.

* Hsieh MH, Chen YT, Chen YT, Lee YH, Lu J, Chien CL, Chen HF, Ho HN, Yu CJ, Wang ZQ, Teng SC. PARP1 controls KLF4-mediated telomerase expression in stem cells and cancer cells. (2017) NAR, DOI:10.1093/nar/gkx683.



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