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專任教師

王錦堂 教授(特聘教授)

聯絡電話:(02)23123456 轉 88292 or 88293

E-mail: wangjt@ntu.edu.tw

個人資料

專長:

消化道病原菌之分子致病機轉

學歷:

台灣大學臨床醫學所

經歷:

台大醫學院微生物學科教授兼主任 (1999/08-2005/08)
台大醫學院研究發展室主任 (2004~)
台大醫學院附設醫院內科住院醫師 (1984-1989)
台大醫學院附設醫院內科主治醫師 (1989∼)
台大醫學院細菌學科副教授 (1984-1999

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目前進行研究

My research areas include:
(1) Microbiology and molecular biology of Helicobacter pylori     
(2) Transfusion transmitted viral infections.  For the first area the major goals are to identify virulence factors of the bacterium associated with different  clinical diseases. The techniques of phage expression library, transposon shuttle mutagenesis and DNA microarrays are currently used.  For the second area a well characterised cohort is adopted for evaluation of incidence ,clinical outcome, and implication for blood donor screening  in transfusion associated viral infections.
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研究室成員

博士班研究生:劉如芸
碩士班研究生:柯彥溥、朱柏勳、廖婉婷、郭芷華、蘇曼華、呂怡柔
博士後研究員:林稚容、謝佩芳、吳孟娟、陳依吟、鄭伊翔
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研究成果

1. Pan YJ†, Lin TL†, Chen CT, Chen YY, Hsieh PF, Hsu CR, Wu MC, Wang JT.* Genetic analysis of capsular polysaccharide synthesis gene clusters in 79 capsular types of Klebsiella spp. Sci Rep. 2015 Oct 23;5:15573. (†, equal contribution)
2. Hua KF, Yang FL, Chiu HW, Chou JC, Dong WC, Lin CN, Lin CY, Wang JT, Li LH, Chiu HW, Chiu YC, Wu SH. Capsular polysaccharide is involved in NLRP3 inflammasome activation by Klebsiella pneumoniae serotype K1. Infect Immun. 2015 Sep;83(9):3396-409.
3. Lin YT†, Pan YJ†, Lin TL, Fung CP, Wang JT.* Transfer of CMY-2 cephalosporinase from Escherichia coli to virulent Klebsiella pneumoniae causing a recurrent liver abscess. Antimicrob Agents Chemother. 2015 Aug;59(8):5000-2. (†, equal contribution)
4. Hsieh YC, Lin TL, Lin CM, Wang JT.* Identification of PblB mediating galactose-specific adhesion in a successful Streptococcus pneumoniae clone. Sci Rep. 2015 Jul 21;5:12265.
5. Cheng YH, Lin TL, Pan YJ, Wang YP, Lin YT, Wang JT.* Colistin resistance mechanisms in Klebsiella pneumoniae strains from Taiwan. Antimicrob Agents Chemother. 2015 May;59(5):2909-13.
6. Eriksson H, Maciejewska B, Latka A, Majkowska-Skrobek G, Hellstrand M, Melefors Ö, Wang JT, Kropinski AM, Drulis-Kawa Z, Nilsson AS. A suggested new bacteriophage genus, "Kp34likevirus", within the Autographivirinae subfamily of Podoviridae. Viruses. 2015 Apr 7;7(4):1804-22.
7. Hsu CR, Pan YJ, Liu JY, Chen CT, Lin TL, Wang JT.* Klebsiella pneumoniae translocates across the intestinal epithelium via Rho GTPase- and phosphatidylinositol 3-kinase/Akt-dependent cell invasion. Infect Immun. 2015 Feb;83(2):769-79.
8. Pan YJ†, Lin TL†, Lin YT, Su PA, Chen CT, Hsieh PF, Hsu CR, Chen CC, Hsieh YC, Wang JT.* Identification of capsular types in carbapenem-resistant Klebsiella pneumoniae strains by wzc sequencing and implications for capsule depolymerase treatment. Antimicrob Agents Chemother. 2015 Feb;59(2):1038-47. (†, equal contribution)
9. Lin TL, Chuang YP, Huang YT, Hsieh PF, Lin YT, Wang JT.* Identification of an immuno-dominant protein from Klebsiella pneumoniae strains causing pyogenic liver abscess: implication in serodiagnosis. BMC Microbiol. 2014 Dec 21;14:321.
10. Lin TL, Hsieh PF, Huang YT, Lee WC, Tsai YT, Su PA, Pan YJ, Hsu CR, Wu MC, Wang JT.* Isolation of a bacteriophage and its depolymerase specific for K1 capsule of Klebsiella pneumoniae: implication in typing and treatment. J Infect Dis. 2014 Dec 1;210(11):1734-44.
11.Hsieh PF, Wu MC, Yang FL, Chen CT, Lou TC, Chen YY, Wu SH, Sheu JC, Wang JT.* D-galactan II is an immunodominant antigen in O1 lipopolysaccharide and affects virulence in Klebsiella pneumoniae: implication in vaccine design. Front Microbiol. 2014 Nov 19;5:608.
12.Alsaedi A, Janower A, Wang JT, Nichol K, Karlowsky J, Orr P, Keynan Y. Hypermucoviscous Klebsiella syndrome without liver abscess in a patient with immunoglobulin g2 immune deficiency. Open Forum Infect Dis. 2014 Sep 9;1(2):ofu080.
13.Puah SM, Puthucheary SD, Wang JT, Pan YJ, Chua KH. Molecular characterization of putative virulence determinants in Burkholderia pseudomallei. ScientificWorldJournal. 2014;2014:590803.
14.Hunt JJ, Astley R, Wheatley N, Wang JT, Callegan MC. TLR4 contributes to the host response to Klebsiella intraocular infection. Curr Eye Res. 2014 Aug;39(8):790-802.
15.Pan YJ, Lin TL, Chen YH, Hsu CR, Hsieh PF, Wu MC, Wang JT.* Capsular types of Klebsiella pneumoniae revisited by wzc sequencing. PLoS One. 2013 Dec 9;8(12):e80670.
16.Hsieh PF, Liu JY, Pan YJ, Wu MC, Lin TL, Huang YT, Wang JT.* Klebsiella pneumoniae peptidoglycan-associated lipoprotein and murein lipoprotein contribute to serum resistance, antiphagocytosis, and proinflammatory cytokine stimulation. J Infect Dis. 2013 Nov 15;208(10):1580-9.
17.Wang CH, Li ST, Lin TL, Cheng YY, Sun TH, Wang JT, Cheng TJ, Mong KK, Wong CH, Wu CY. Synthesis of Neisseria meningitidis serogroup W135 capsular oligosaccharides for immunogenicity comparison and vaccine development. Angew Chem Int Ed Engl. 2013 Aug 26;52(35):9157-61.
18.Hsu CR, Lin TL, Pan YJ, Hsieh PF, Wang JT.* Isolation of a bacteriophage specific for a new capsular type of Klebsiella pneumoniae and characterization of its polysaccharide depolymerase. PLoS One. 2013 Aug 2;8(8):e70092.
19.Hsieh YC, Lin TL, Chang KY, Huang YC, Chen CJ, Lin TY, Wang JT.* Expansion and evolution of Streptococcus pneumoniae serotype 19A ST320 clone as compared to its ancestral clone, Taiwan19F-14 (ST236). J Infect Dis. 2013 Jul 15;208(2):203-10.
20.Lin TL†, Yang FL†, Yang AS, Peng HP, Li TL, Tsai MD, Wu SH, Wang JT.* Amino acid substitutions of MagA in Klebsiella pneumoniae affect the biosynthesis of the capsular polysaccharide. PLoS One. 2012 Oct;7(10):e46783. (†, equal contribution)
21.Lai CC, Lee PL, Tan CK, Huang YT, Kao CL, Wang JT, Hsueh PR. Pneumonia due to pandemic (H1N1) 2009 influenza virus and Klebsiella pneumoniae capsular serotype K16 in a patient with nasopharyngeal cancer. J Microbiol Immunol Infect. 2012 Oct;45(5):382-4.
22.Lin LL, Huang HC, Ogihara S, Wang JT, Wu MC, McNeil PL, Chen CN, Juan HF. Helicobacter pylori disrupts host cell membranes, initiating a repair response and cell proliferation. Int J Mol Sci. 2012 Aug;13(8):10176-92.
23.Wu MC, Chen YC, Lin TL, Hsieh PF, Wang JT.* Cellobiose-specific phosphotransferase system of Klebsiella pneumoniae and its importance in biofilm formation and virulence. Infect Immun. 2012 Jul;80(7):2464-72.
24.Hsieh PF, Lin TL, Yang FL, Wu MC, Pan YJ, Wu SH, Wang JT.* Lipopolysaccharide O1 antigen contributes to the virulence in Klebsiella pneumoniae causing pyogenic liver abscess. PLoS One. 2012 Mar;7(3):e33155.
25.Yu LC, Wang JT, Wei SC, Ni YH. Host-microbial interactions and regulation of intestinal epithelial barrier function: From physiology to pathology. World J Gastrointest Pathophysiol. 2012 Feb 15;3(1):27-43.
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