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Full-Time

Shu-Chun Teng Professor

聯絡電話:02-2312-3456 ext. 88294 (O), 88282 (L)

E-mail: shuchunteng@ntu.edu.tw

Personal File

Field:

chromosome dynamics, cell cycle regulation, telomeres, DNA repair

Education:

Ph.D. of Biochemistry, Rutgers University

Title:

台大醫學院微生物學科, Professor (2007.08~)
台大醫學院微生物學科, Associate Professor (2003~2007)
台大醫學院微生物學科, Assistant Professor (2000~2003)
普林斯頓大學分子生物學系, Visiting Fellow (1997~2000)

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Current Research

The overall goal of our laboratory is to gain insight into the molecular basis of genome dynamics and stress in cancer and aging by systematically identifying both enzymatic and structural components involved in the chromosome dynamics, stress response and aging pathways, and characterizing how these proteins work. Genomic instability is the leading cause for disease and telomere maintenance is a required step for cancer and aging. We take advantage of the genetically tractable model organisms yeast Saccharomyces cerevisiae and Schizosaccharomyces pombe to approach these questions and use our findings in yeast to extend our studies in mammalian cells, since the fundamental mechanisms of these pathways are preserved from yeast to human.

The Teng laboratory is always eager to hear from students and postdoctors who are ambitious, dedicated, love science and are interested in doing research with us.

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Staff members

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Selected publications

Selected Publications:

* Tseng SF, Gabriel A, Teng SC. Proofreading activity of DNA polymerase Pol2 mediates 3’-end processing during nonhomologous end joining in yeast. (2008) PLoS Genetics, 4(4):e1000060

* Tseng SF, Shen ZJ, Tsai HJ, Lin YH, Teng SC. Rapid Cdc13 turnover and telomere length homeostasis are controlled by Cdk1-mediated phosphorylation of Cdc13. (2009) NAR, 37, 3602-11.

* Lu CY, Tsai CH, Brill SJ, Teng SC. Sumoylation of the BLM ortholog, Sgs1, promotes telomere-telomere recombination in budding yeast. (2010) NAR, 38, 488-498.

* Wong CW, Hou PS, Tseng SF, Chien CL, Wu KJ, Chen HF, Ho HN, Kyo S, Teng SC. KLF4 contributes to maintenance of telomerase activity in stem cells. (2010) Stem Cells, 28, 1510-7.

* Huang YC, Chen HT, Teng SC. Intragenic transcription of a non-coding RNA modulates expression of ASP3 in budding yeast. (2010) RNA, 16, 2085-93.

* Wu MZ, Tsai YP, Yang MH, Huang CH, Chang SY, Chang CC, Teng SC, Wu KJ. Interplay between HDAC3 and WDR5 is essential for hypoxia-induced epithelial-mesenchymal transition. (2011) Mol Cell, 43, 811-22.

* Kao L, Wang YT, Chen YC, Tseng SF, Jhang JC, Chen YJ, Teng SC. Global analysis of Cdc14 dephosphorylation sites reveals essential regulatory role in mitosis and cytokinesis. (2014) Molecular & Cellular Proteomics, 13, 594-605.

* Shen ZJ, Hsu PH, Su YT, Yang CW, Kao L, Tseng SF, Tsai MD, Teng SC. PP2A and Aurora differentially modify Cdc13 to promote telomerase release from telomeres at G2/M phase. (2014) Nature Communications, 5:5312 doi: 10.1038/ncomms6312.

* Chang YL, Hsieh MH, Chang WW, Wang HY, Lin MC, Wang CP, Lou PJ, Teng SC. Instability of succinate dehydrogenase in SDHD polymorphism connects reactive oxygen species production to nuclear and mitochondrial genomic mutations in yeast. (2015) Antioxidants & Redox Signaling, 22, 587-602

* Hsieh MS, Tsai CH, Lin CC, Li TK, Hung TW, Chang LT, Hsin LW, Teng SC. Topoisomerase II inhibition suppresses the proliferation of telomerase-negative cancers. (2015) Cellular and Molecular Life Sciences, 72, 1825-1837

* Tsai CH, Chen YJ, Yu CJ, Tzeng SR, Wu IC, Kuo WH, Lin MC, Chan NL, Wu KJ, Teng SC. SMYD3-mediated H2A.Z.1 methylation promotes cell cycle and cancer proliferation. (2016) Cancer Research, 76, 6043-6053
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